Pipeline
ASAP direct-acting antiviral discovery programs and research outputs
Discovery Program
For data from the COVID Moonshot predecessor program, please see the preprint, COVID Moonshot data portal, and Fragalysis X-ray structure hub.
ASAP Resources
ASAP maintains several open community resources to help foster a global antiviral discovery pipeline:
- Mutational fitness scans from analysis of circulating variants: SARS-CoV-2
- Wetlab protocols are hosted at the ASAP protocols.io page
- ASAP talks and datasets at the ASAP Zenodo Community
- ASAP plasmid resources are available through the ASAP AddGene page under the permissive OpenMTA whenever possible
- ASAP compounds are available through Enamine without the need for an MTA
- Recorded talks on the ASAP YouTube and Open Antivirals YouTube channels
- The Open Antiviral Discovery Forum enables multiple AViDD Centers to rapidly share information and resources for antiviral drug discovery
ASAP Research Outputs
ASAP is an open science antiviral discovery center that aims to make all research outputs openly available as rapidly as possible to build a global antiviral discovery pipeline. Below, we give an overview of all classes of ASAP’s research outputs:
Viral Family
The viral family describes the family of viruses ASAP aims to develop antivirals against. ASAP aims to discover direct-acting antivirals with broad antiviral activity within a viral family, but the difficulty of achieving this goal means that some of our program objectives are more narrowly focused on viral family members of greatest pandemic concern.
🔎 View all ASAP viral families
Targeting Opportunity
A Targeting Opportunity provides an overview of the opportunity for targeting new antivirals to a specific target protein and mode of action. This overview summarizes relevant information for drug hunters, including the relevant domain and binding sites to target, notable chemical matter, rationale for antiviral effects, and other useful information in prosecuting a discovery compaign against the target.
🔎 View all ASAP Targeting Opportunities
Molecules
ASAP is synthesizing and assaying new molecules against numerous antiviral targets, and posting these publicly as part of our open science mission.
🔎 View all ASAP molecules and assay data
Structures
Diamond Light Source is a full partner in ASAP, producing numerous X-ray structures of molecules bound to antiviral targets.
Publications
ASAP aims to publish preprints of all work to ensure our scientific advances are rapidly and openly available to all.
🔎 View all ASAP Publications
Analysis of circulating variants
ASAP uses the analysis of circulating variants of viruses such as SARS-CoV-2 to identify functionally tolerated mutations to inform resistance-robust inhibitor discovery.
🔎 View all ASAP analysis of circulating variant data
Deep mutational scanning
Deep mutational scanning (DMS) data helps identify mutations in the target that are functionally tolerated and could lead to resistance should these mutations abrogate binding of antivirals. ASAP is using multiple techniques to rapidly generate DMS data for all targets of interest in order to inform the discovery of resistance-robust direct-acting antivirals.
🔎 View all ASAP deep mutational scanning data
Target Product Profile (TPP)
A Target Product Profile (TPP) describes the desired characteristics of a drug product aimed to treat a particular disease or set of diseases. All ASAP TPPs are draft TPPs intended to help guide the development of target candidate profiles (TCPs) for antiviral discovery within the ASAP Discovery Consortium. ASAP works with stakeholders around the globe (such as the World Health Organization) to align TPPs to ensure they meet the needs of communities and fulfill our mission of global, equitable, and affordable access to antiviral therapies.
🔎 View all ASAP Target Product Profiles (TPPs)
Target Candidate Profile (TCP)
A Target Candidate Profile (TCP) describes the objectives an ASAP drug discovery program aims to achieve to produce a preclinical candidate. Our TCPs are informed by the corresponding Target Product Profiles (TPPs) for the corresponding disease.
🔎 View all ASAP Target Candidate Profiles (TCPs)
Assay cascades
An assay cascade is a defined set of assays and progression criteria used by a drug discovery program to achieve its Target Candidate Profile (TCP) goals in a time- and cost-effective manner.
🔎 View all ASAP assay cascades
Target Enabling Package (TEP)
A Target Enabling Package (TEP) is a complete data package needed to enable structure-based drug discovery against an antiviral target. Pioneered by the Structural Genomics Consortium, each TEP contains relevant protein constructs and plasmid resources for one or more viral family members, protein expression and purification protocols, crystallization conditions, structures from an X-ray fragment screen at the Diamond Light Source XChem facility, small molecule hits, and biochemical assay protocols with at least one validated inhibitor with quantifiable activity.
🔎 View all ASAP Target Enabling Packages (TEPs)
Hit-to-Lead Progression
ASAP aims to produce high-quality lead compounds for nine viral targets within five years.
🔎 View all ASAP molecules and assay data
Covalent Targeting
ASAP is exploring covalent targeting strategies for cysteine and serine proteases.
🔎 View all ASAP molecules and assay data
Lead Optimization
ASAP aims to pursue five lead optimization programs within five years, producing at least three candidates for preclinical development
🔎 View all ASAP molecules and assay data
Preclinical programs
ASAP aims to prosecute three IND-enabling preclinical programs within five years.
🔎 View all ASAP preclinical programs
Investigational New Drug (IND) filings
ASAP aims to produce three IND filings within five years.
🔎 View all ASAP Investigational New Drugs (INDs)
Clinical trials
ASAP collaborates with downstream translational partners to carry the clinical candidates it discovers into clinical trials. Note that the AViDD U19 grant held by ASAP is not used to fund clinical trials.
🔎 View all ASAP clinical trials
New Drug Approval (NDA)
ASAP aims to work with partners to seek New Drug Approvals (NDAs) and carry our antivirals to manufacture with the goal of globally accessible and affordable therapeutics.