Members

ASAP Personnel

Principal Investigators

Alpha Lee

Principal Investigator; Project Lead: Hit-to-lead
Co-Founder and Chief Scientific Officer, PostEra
web: http://postera.ai
ORCID: 0000-0002-9616-3108 | Google Scholar Oversight of early-stage discovery; artificial intelligence and machine learning for virtual synthetic libraries and automated ligand optimization; automated hit-to-lead optimization

John D. Chodera

Principal Investigator; Co-Investigator: Hit-to-Lead; Co-Investigator: Lead Optimization
Associate Member, Sloan Kettering Institute
web: http://choderalab.org
ORCID: 0000-0003-0542-119X | Google Scholar Contact PI; Oversight of cores; Alchemical free energy calculations on Folding@home; computational chemistry and structure-based machine learning

Peter Sjö

Principal Investigator; Co-Investigator: Preclinical Development
Head of Drug Discovery Programme, Drugs for Neglected Diseases initiative (DNDi)
web: https://dndi.org/our-people/peter-sjo/
ORCID: 0000-0002-6768-0536 | Google Scholar Oversight of late-stage discovery and preclinical development; preclinical development; medicinal chemistry

Project Leads

Alpha Lee

Annette von Delft

Project Lead: Preclinical Development
Translational Scientist, MedChemica Ltd
web: https://www.linkedin.com/in/annette-von-delft-56113093/?originalSubdomain=uk
| Google Scholar translational science; preclinical development

Ed Griffen

Project Lead: Lead Optimization
Technical Director, MedChemica Consultancy Ltd and MedChemical Ltd, MedChemica Ltd
web: https://www.target2035.net/biosketches/ed-griffen-medchemica-ltd
| Google Scholar Project Lead: Lead Optimization; medicinal chemistry; lead optimization; hit-to-lead

Frank von Delft

Project Lead: Target enablement ; Core Lead: Structural Biology Core
Principal Beamline Scientist, MX beamline I04-1 and XChem, Diamond Light Source
web: https://www.diamond.ac.uk/Instruments/Mx/Fragment-Screening.html
ORCID: 0000-0003-0378-0017 | Google Scholar Project 2 Lead: Target enablement; Structural Biology Core Lead; high-throughput structural biology; fragment screening

Karla Kirkegaard

Project Lead
Violetta L. Horton Professor, Department of Genetics, Stanford University School of Medicine
web: https://web.stanford.edu/group/kirkegaard/karla.html
ORCID: 0000-0001-7628-3770 | Google Scholar Project 1 Lead: Antiviral Targeting to Suppress Drug Resistance

Nir London

Project Lead: Covalent Targeting Strategies; Core Lead: Biochemical Assay Core
Senior Scientist (Assistant Professor), Weizmann Institute of Science
web: https://www.weizmann.ac.il/Organic_Chemistry/London/home
ORCID: 0000-0003-2687-0699 | Google Scholar Project Lead: Covalent Tareting Strategies

Core Leads

Frank von Delft

Kris White

Core Lead: Antiviral Efficacy and Resistance Core
Assistant Professor, Icahn School of Medicine at Mount Sinai
web: https://labs.icahn.mssm.edu/garcia-sastre/kris-white-ph-d/
ORCID: 0000-0003-0889-0506 Core Lead: Antiviral Efficacy and Resistance Core; animal efficacy models; antiviral assays

Matthew Robinson

Core Lead: Data Infrastructure Core
Chief Technology Officer, PostEra
web: https://postera.ai/about/
Core Lead: Data Infrastructure Core

Nir London

Co-Investigators

Adolfo García-Sastre

Co-Investigator: Antiviral Efficacy and Resistance Core
Professor of Microbiology, Icahn School of Medicine at Mount Sinai
Antiviral Efficacy and Resistance Core
web: https://icahn.mssm.edu/profiles/adolfo-garcia-sastre
ORCID: 0000-0002-6551-1827 virology; antiviral discovery; viral resistance

Celia Schiffer

Co-Investigator
Co-Investigator, UMass Chan Medical School
P1: Antiviral targeting
Co-Investigator

Dan Bolon

Co-Investigator
Co-Investigator, UMass Chan Medical School
P1: Antiviral targeting
ORCID: https://orcid.org/0000-0001-5857-6676 Co-Investigator

Daren Fearon

Co-Investigator: Structural Biology Core
Senior Beamline Scientist, Diamond Light Source
Structural Biology Core
web: https://www.diamond.ac.uk/Instruments/Mx/Fragment-Screening/XChem-Team/Fearon.html
ORCID: 0000-0003-3529-7863 high throughput X-ray structural biology; X-ray fragment screening; X-ray structure solution

Haim Barr

Co-Investigator: Biochemical Assay Core
Head of Drug Discovery and Medicinal Chemistry, INCPM, Weizmann Institute of Science
P1: Biochemical Assay Core
P1: Biochemical Assay Core
web: https://www.linkedin.com/in/haim-barr-4894907/?originalSubdomain=il
| Google Scholar assay development; high-throughput biochemical assays

Jesse Bloom

Co-Investigator: Antiviral Targeting to Suppress Resistance
Associate Professor, Fred Hutchinson Cancer Research Center; Investigator, Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center; Howard Hughes Medical Institute
P1: Antiviral targeting
web: https://www.fredhutch.org/en/faculty-lab-directory/bloom-jesse.html
ORCID: 0000-0003-1267-3408 | Google Scholar deep mutational scanning; viral bioinformatics; antiviral resistance

John D. Chodera

Laurent Fraisse

Co-Investigator: Preclinical Development
Research and Development Director, Drugs for Neglected Diseases initiative (DNDi)
P6: Preclinical Development
web: https://dndi.org/our-people/laurent-fraisse/
preclinical development; neglected diseases; global equitable access

Martin Walsh

Co-Investigator: Target Enablement; Co-Investigator: Structural Biology Core
Deputy Director of Life Sciences, Diamond Light Source
web: https://www.diamond.ac.uk/Instruments/Mx/Research/Walsh-group/Staff/Martin-Walsh.html
ORCID: 0000-0001-5683-1151 protein expression; high throughput X-ray structural biology; X-ray fragment screening; X-ray structure solution

Matt Bogyo

Co-Investigator
Professor of Pathology, Professor of Microbiology and Immunology, Professor by courtesy of Chemical and Systems Biology, Stanford University School of Medicine
web: https://med.stanford.edu/bogyolab.html
ORCID: 0000-0003-3753-4412 protease targeting; covalent targeting strategies

Matt Evans

Co-Investigator
Co-Investigator, Mount Sinai
P1: Antiviral targeting
ORCID: 0000-0002-4991-3877 Co-Investigator

Pascale Boulet

Co-Investigator
ASAP IP Strategy Consultant, Intellectual Property & Access Leader, DNDi., Drugs for Neglected Diseases Initiative (DNDi)
P6: Preclinical development
ORCID: https://orcid.org/0000-0003-0542-119X Regulatory

Peter Sjö

Randy Albrecht

Co-Investigator: Antiviral Resistance and Efficacy Core
Associate Professor, Icahn School of Medicine at Mount Sinai
web: https://www.mountsinai.org/profiles/randy-a-albrecht
| Google Scholar virology; animal efficacy models of viral respiratory disease

Scientists and Collaborators

Adolfo García-Sastre

Akbar Ali

, UMass Chan Medical School
P1: Antiviral targeting

Ala Shaqra

Scientist
Scientist, UMass Chan Medical School
P1: Antiviral targeting
Scientist

Alexander Matthew Payne

Researcher: Computational Chemistry Core
PhD Candidate, Memorial Sloan Kettering Center for Cancer Research
web: https://linktr.ee/alexandermatthewpayne
ORCID: 0000-0003-0947-0191 | Google Scholar docking; free energy calculations; pan-family design

Alpha Lee

Andre Schützer de Godoy

Scientist
Professor, Universidade de São Paulo (USP). Instituto de Física de São Carlos (IFSC)
web: https://bv.fapesp.br/en/pesquisador/80962/andre-schutzer-de-godoy/
ORCID: 0000-0002-0613-9164 | Google Scholar structural biology; cryo-EM; X-ray structures; protein biochemistry; SARS-CoV-2 proteases

Annette von Delft

Benjamin Kaminow

Unfunded collaborator
Unfunded collaborator, Sloan Kettering Institute for Cancer Research
Computational Chemistry Core
ORCID: https://orcid.org/0000-0002-2266-3353 Unfunded collaborator

Benjamin Perry

Former PI
Former PI, Drugs for Neglected Diseases Initiative
Former PI

Blake Balcomb

Post Doc
Post Doc, Diamond Light Source
Structural Biology Core
ORCID: https://orcid.org/0000-0001-7599-8467 Post Doc

Brian Marsden

Other Personnel
Other Personnel, University of Oxford
P2: Target enablement
ORCID: https://orcid.org/0000-0002-1937-4091 Other Personnel

Briana McGovern

Scientist
Scientist, Mount Sinai
Antiviral Efficacy and Resistance Core
ORCID: https://orcid.org/0000-0002-0492-9904 Scientist

Bruce Lefker

Consultant
Consultant, Thames Pharma Partners
P3: Fragment-to-lead and target validation, P5: Lead optimization
Consultant

Charlie Tomlinson

Scientist
Scientist, Diamond Light Source
Structural Biology Core
ORCID: https://orcid.org/0000-0002-1845-6028 Scientist

Charline Giroud

Scientist
Scientist, University of Oxford
P2: Target enablement
Scientist

Conor Wild

Post Doc
Post Doc, Diamond Light Source
P2: Target enablement, Structural Biology Core
P2: Target enablement, Structural Biology Core
ORCID: https://orcid.org/0000-0003-0654-8141 Post Doc

Dan James

Software Engineer
Software Engineer, MedChemica
P5: Lead optimization
Software Engineer

Daren Fearon

David Cousins

Scientist
Scientist, MedChemica
P5: Lead optimization
ORCID: 0000-0001-9945-769X Scientist

David Dotson

Scientist
Scientist, Sloan Kettering Institute for Cancer Research
Computational Chemistry Core
ORCID: https://orcid.org/0000-0001-5879-2942 Scientist

Ed Griffen

Eleanor Williams

Scientific Coordinator
Scientific Coordinator, University of Oxford
P2: Target enablement
ORCID: 0000-0002-1331-9518 Scientific Coordinator

Emily Ripka

Software Engineer
Software Engineer, PostEra Inc.
Data Core
Software Engineer

Frank von Delft

Gwendolyn Fate

Consultant
Consultant, Thames Pharma Partners
P6: Preclinical development and translation
Consultant

Haim Barr

Haitem Elmassoudi

Scientist
Scientist, University of Oxford
P2: Target enablement
Scientist

Hugo Macdermott-Opeskin

Consultant
Consultant, Sloan Kettering Institute for Cancer Research
Computational Chemistry Core
ORCID: https://orcid.org/0000-0002-7393-7457 Consultant

Isabelle Amick

Scientist
Scientist, PostEra Inc.
P3: Fragment-to-lead and target validation
ORCID: https://orcid.org/0000-0001-7876-4842 Scientist

Iván Pulido

Software Engineer
Software Engineer, Sloan Kettering Institute for Cancer Research
Computational Chemistry Core
ORCID: https://orcid.org/0000-0002-7178-8136 Software Engineer

Jared Benjamin

Scientist
Scientist, Mount Sinai
Antiviral Efficacy and Resistance Core
ORCID: https://orcid.org/0000-0002-0328-0461 Scientist

Jasmin Aschenbrenner

Post Doc
Post Doc, Diamond Light Source
Structural Biology Core
ORCID: https://orcid.org/0000-0002-4318-0481 Post Doc

Jenke Scheen

Researcher
Scientist, Open Molecular Software Foundation
web: https://www.linkedin.com/in/jenkescheen/
ORCID: 0000-0001-9781-0445 | Google Scholar Alchemical free energy calculations on Folding@home; project support

Jerry Yap

Scientist
Medicinal Chemist, PostEra Inc.
Computational Chemistry Core, Data Core, P3: Fragment-to-lead and target validation
Computational Chemistry Core, Data Core, P3: Fragment-to-lead and target validation

Jesse Bloom

Jessica Stacey

Scientist
Scientist, MedChemica
P5: Lead optimization
ORCID: 0000-0001-6932-8539 Scientist

John D. Chodera

Julia Flynn

, UMass Chan Medical School
P1: Antiviral targeting

Kate Fieseler

, University of Oxford
P2: Target enablement
ORCID: 0000-0003-0211-8558

Kris White

Lauren Reid

Scientist
Scientist, MedChemica
P5: Lead optimization
ORCID: https://orcid.org/0000-0001-8327-0927 Scientist

Laurent Fraisse

Lizbe Koekemoer

Scientific Coordinator
Scientific Coordinator, University of Oxford
P2: Target enablement
ORCID: https://orcid.org/0000-0001-9226-9127 Scientific Coordinator

Lucas Ferreira

Other Personnel
Other Personnel, University of Oxford
P2: Target enablement
ORCID: https://orcid.org/0000-0001-6397-357X Other Personnel

Mario Rodríguez Monteverde

Scientist
Scientist, Mount Sinai
Antiviral Efficacy and Resistance Core
Scientist

Martin Walsh

Matteo Ferla

Post Doc
Post Doc, University of Oxford
P2: Target enablement
ORCID: https://orcid.org/0000-0002-5508-4673 Post Doc

Matthew Robinson

Core Lead: Data Infrastructure Core
Chief Technology Officer, PostEra
web: https://postera.ai/about/
Core Lead: Data Infrastructure Core

Melissa Boby

Unfunded collaborator
Unfunded collaborator, Sloan Kettering Institute for Cancer Research
Computational Chemistry Core
ORCID: https://orcid.org/0000-0003-1920-206X Unfunded collaborator

Michael Fairhead

Post Doc
Post Doc, University of Oxford
P2: Target enablement
ORCID: 0000-0001-5361-3933 Post Doc

Michael Retchin

Student
Student, Sloan Kettering Institute for Cancer Research
Computational Chemistry Core
ORCID: https://orcid.org/0000-0001-9822-8318 Student

Michael Williams

Scientist
Scientist, Mount Sinai
Antiviral Efficacy and Resistance Core
Scientist

Mike Henry

Scientist
Scientist, Sloan Kettering Institute for Cancer Research
Computational Chemistry Core
ORCID: 0000-0002-3870-9993 Scientist

Nese Kurt Yilmaz

, UMass Chan Medical School
P1: Antiviral targeting

Nir London

Noa Lahav

Scientist
Scientist, Weizmann Institute of Science
Biochemical Assay Core
ORCID: N/A Scientist

Oleg Fedorov

Other Personnel
Other Personnel, University of Oxford
P2: Target enablement
Other Personnel

Peter Marples

Research Assistant
Research Assistant, Diamond Light Source
P2: Target enablement, Structural Biology Core
P2: Target enablement, Structural Biology Core
ORCID: 0000-0002-8787-7969 Research Assistant

Peter Sjö

Qiu Yu Huang

, UMass Chan Medical School
P1: Antiviral targeting

Ralph Robinson

Consultant
Consultant, Thames Pharma Partners
P3: Fragment-to-lead and target validation, P5: Lead optimization
Consultant

Randy Albrecht

Randy Diaz-Tapia

Scientist
Scientist, Mount Sinai
Antiviral Efficacy and Resistance Core
Scientist

Rebecca Hertzman

Student
Student, Weizmann Institute of Science
P4: Covalent targeting strategies
Student

Romel Rosales

Post Doc
Post Doc, Mount Sinai
Antiviral Efficacy and Resistance Core
Post Doc

Ruben Garcia Sanchez

Post Doc
Post Doc, University of Oxford
P2: Target enablement
ORCID: https://orcid.org/0000-0001-6156-3542 Post Doc

Ryan Lithgo

Post Doc
Post Doc, Diamond Light Source
Structural Biology Core
ORCID: https://orcid.org/0000-0002-4706-9916 Post Doc

Sarah Duggan

, UMass Chan Medical School
P1: Antiviral targeting
ORCID: https://orcid.org/0000-0003-0282-1809

Tamas Szommer

Scientific Coordinator
, University of Oxford
P2: Target enablement
ORCID: 0000-0002-3811-4068

Thomas Vargo

Scientist
Scientist, PostEra Inc.
P3: Fragment-to-lead and target validation
Scientist

Tyler Starr

Postdoctoral Research Fellow: Antiviral Targeting to Suppress Resistance
Associate Professor, Fred Hutchinson Cancer Research Center, Fred Hutchinson Cancer Research Center
web: https://www.linkedin.com/in/tyler-starr-06a1b3172/
ORCID: 0000-0001-6713-6904 | Google Scholar deep mutational scanning; viral bioinformatics; antiviral resistance

Warren Thompson

Post Doc
Post Doc, Diamond Light Source
P2: Target enablement, Structural Biology Core
P2: Target enablement, Structural Biology Core
ORCID: 0000-0003-1474-7810 Post Doc

Xiaomin Ni

Scientist
Scientist, University of Oxford
P2: Target enablement
ORCID: https://orcid.org/0000-0002-7769-8297 Scientist

Administrative Core

Ashley Souffront

Project manager
Project manager, Sloan Kettering Institute for Cancer Research
Administrative Core
Project manager

Erica Goldberger

Unfunded collaborator
Unfunded collaborator, Sloan Kettering Institute for Cancer Research
Administrative Core
ORCID: 0000-0002-0642-7107 Unfunded collaborator

Jessie Slater

Other Personnel
Other Personnel, Sloan Kettering Institute for Cancer Research
Administrative Core
Other Personnel

Maggie Jameson

Administrative Director
Administrative Director, Sloan Kettering Institute for Cancer Research
Administrative Core
Administrative Director