Members

ASAP Investigators

Principal Investigators

Alpha Lee

Principal Investigator; Project Lead: Hit-to-lead
Co-Founder and Chief Scientific Officer, PostEra
Oversight of early-stage discovery; artificial intelligence and machine learning for virtual synthetic libraries and automated ligand optimization; automated hit-to-lead optimization
web: http://postera.ai
ORCID: 0000-0002-9616-3108 | Google Scholar

John D. Chodera

Principal Investigator; Co-Investigator: Hit-to-Lead; Co-Investigator: Lead Optimization
Associate Member, Sloan Kettering Institute
Contact PI; Oversight of cores; Alchemical free energy calculations on Folding@home; computational chemistry and structure-based machine learning
web: http://choderalab.org
ORCID: 0000-0003-0542-119X | Google Scholar

Peter Sjö

Principal Investigator; Co-Investigator: Preclinical Development
Head of Drug Discovery Programme, Drugs for Neglected Diseases initiative (DNDi)
Oversight of late-stage discovery and preclinical development; preclinical development; medicinal chemistry
web: https://dndi.org/our-people/peter-sjo/
ORCID: 0000-0002-6768-0536 | Google Scholar

Project Leads

Alpha Lee

Annette von Delft

Project Lead: Preclinical Development
Translational Scientist, MedChemica Ltd
translational science; preclinical development
web: https://www.linkedin.com/in/annette-von-delft-56113093/?originalSubdomain=uk
| Google Scholar

Ed Griffen

Project Lead: Lead Optimization
Technical Director, MedChemica Consultancy Ltd and MedChemical Ltd, MedChemica Ltd
Project Lead: Lead Optimization; medicinal chemistry; lead optimization; hit-to-lead
web: https://www.target2035.net/biosketches/ed-griffen-medchemica-ltd
| Google Scholar

Frank von Delft

Project Lead: Target enablement ; Core Lead: Structural Biology Core
Principal Beamline Scientist, MX beamline I04-1 and XChem, Diamond Light Source
Project 2 Lead: Target enablement; Structural Biology Core Lead; high-throughput structural biology; fragment screening
web: https://www.diamond.ac.uk/Instruments/Mx/Fragment-Screening.html
ORCID: 0000-0003-0378-0017 | Google Scholar

Karla Kirkegaard

Project Lead
Violetta L. Horton Professor, Department of Genetics, Stanford University School of Medicine
Project 1 Lead: Antiviral Targeting to Suppress Drug Resistance
web: https://web.stanford.edu/group/kirkegaard/karla.html
ORCID: 0000-0001-7628-3770 | Google Scholar

Nir London

Project Lead: Covalent Targeting Strategies; Core Lead: Biochemical Assay Core
Senior Scientist (Assistant Professor), Weizmann Institute of Science
Project Lead: Covalent Tareting Strategies
web: https://www.weizmann.ac.il/Organic_Chemistry/London/home
ORCID: 0000-0003-2687-0699 | Google Scholar

Core Leads

Frank von Delft

Kris White

Core Lead: Antiviral Efficacy and Resistance Core
Assistant Professor, Icahn School of Medicine at Mount Sinai
Core Lead: Antiviral Efficacy and Resistance Core; animal efficacy models; antiviral assays
web: https://labs.icahn.mssm.edu/garcia-sastre/kris-white-ph-d/
ORCID: 0000-0003-0889-0506

Matthew Robinson

Core Lead: Data Infrastructure Core
Chief Technology Officer, PostEra
Core Lead: Data Infrastructure Core
web: https://postera.ai/about/

Nir London

Co-Investigators

Adolfo García-Sastre

Co-Investigator: Antiviral Efficacy and Resistance Core
Professor of Microbiology, Icahn School of Medicine at Mount Sinai
virology; antiviral discovery; viral resistance
web: https://icahn.mssm.edu/profiles/adolfo-garcia-sastre
ORCID: 0000-0002-6551-1827

Daren Fearon

Co-Investigator: Structural Biology Core
Senior Beamline Scientist, Diamond Light Source
high throughput X-ray structural biology; X-ray fragment screening; X-ray structure solution
web: https://www.diamond.ac.uk/Instruments/Mx/Fragment-Screening/XChem-Team/Fearon.html
ORCID: 0000-0003-3529-7863

Haim Barr

Co-Investigator: Biochemical Assay Core
Head of Drug Discovery and Medicinal Chemistry, INCPM, Weizmann Institute of Science
assay development; high-throughput biochemical assays
web: https://www.linkedin.com/in/haim-barr-4894907/?originalSubdomain=il
| Google Scholar

Jesse Bloom

Co-Investigator: Antiviral Targeting to Suppress Resistance
Associate Professor, Fred Hutchinson Cancer Research Center; Investigator, Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center; Howard Hughes Medical Institute
deep mutational scanning; viral bioinformatics; antiviral resistance
web: https://www.fredhutch.org/en/faculty-lab-directory/bloom-jesse.html
ORCID: 0000-0003-1267-3408 | Google Scholar

John D. Chodera

Laurent Fraisse

Co-Investigator: Preclinical Development
Research and Development Director, Drugs for Neglected Diseases initiative (DNDi)
preclinical development; neglected diseases; global equitable access
web: https://dndi.org/our-people/laurent-fraisse/

Martin Walsh

Co-Investigator: Target Enablement; Co-Investigator: Structural Biology Core
Deputy Director of Life Sciences, Diamond Light Source
protein expression; high throughput X-ray structural biology; X-ray fragment screening; X-ray structure solution
web: https://www.diamond.ac.uk/Instruments/Mx/Research/Walsh-group/Staff/Martin-Walsh.html
ORCID: 0000-0001-5683-1151

Matt Bogyo

Co-Investigator
Professor of Pathology, Professor of Microbiology and Immunology, Professor by courtesy of Chemical and Systems Biology, Stanford University School of Medicine
protease targeting; covalent targeting strategies
web: https://med.stanford.edu/bogyolab.html
ORCID: 0000-0003-3753-4412

Peter Sjö

Randy Albrecht

Co-Investigator: Antiviral Resistance and Efficacy Core
Associate Professor, Icahn School of Medicine at Mount Sinai
virology; animal efficacy models of viral respiratory disease
web: https://www.mountsinai.org/profiles/randy-a-albrecht
| Google Scholar

Collaborators

Andre Schützer de Godoy

Collaborator
Professor, Universidade de São Paulo (USP). Instituto de Física de São Carlos (IFSC)
structural biology; cryo-EM; X-ray structures; protein biochemistry; SARS-CoV-2 proteases
web: https://bv.fapesp.br/en/pesquisador/80962/andre-schutzer-de-godoy/
ORCID: 0000-0002-0613-9164 | Google Scholar