Members
ASAP Personnel
Principal Investigators

Alpha Lee

Principal Investigator; Project Lead: Hit-to-lead
Co-Founder and Chief Scientific Officer, PostEra
web: http://postera.ai
ORCID: 0000-0002-9616-3108
| Google Scholar
Oversight of early-stage discovery; artificial intelligence and machine learning for virtual synthetic libraries and automated ligand optimization; automated hit-to-lead optimization

John D. Chodera

Principal Investigator; Co-Investigator: Hit-to-Lead; Co-Investigator: Lead Optimization
Associate Member, Sloan Kettering Institute
web: http://choderalab.org
ORCID: 0000-0003-0542-119X
| Google Scholar
Contact PI; Oversight of cores; Alchemical free energy calculations on Folding@home; computational chemistry and structure-based machine learning

Peter Sjö
Principal Investigator; Co-Investigator: Preclinical Development
Head of Drug Discovery Programme, Drugs for Neglected Diseases initiative (DNDi)
web: https://dndi.org/our-people/peter-sjo/
ORCID: 0000-0002-6768-0536
| Google Scholar
Oversight of late-stage discovery and preclinical development; preclinical development; medicinal chemistry
Project Leads

Alpha Lee

Principal Investigator; Project Lead: Hit-to-lead
Co-Founder and Chief Scientific Officer, PostEra
web: http://postera.ai
ORCID: 0000-0002-9616-3108
| Google Scholar
Oversight of early-stage discovery; artificial intelligence and machine learning for virtual synthetic libraries and automated ligand optimization; automated hit-to-lead optimization

Annette von Delft
Project Lead: Preclinical Development
Translational Scientist, MedChemica Ltd
web: https://www.linkedin.com/in/annette-von-delft-56113093/?originalSubdomain=uk
| Google Scholar
translational science; preclinical development

Ed Griffen

Project Lead: Lead Optimization
Technical Director, MedChemica Consultancy Ltd and MedChemical Ltd, MedChemica Ltd
web: https://www.target2035.net/biosketches/ed-griffen-medchemica-ltd
| Google Scholar
Project Lead: Lead Optimization; medicinal chemistry; lead optimization; hit-to-lead

Frank von Delft

Project Lead: Target enablement ; Core Lead: Structural Biology Core
Principal Beamline Scientist, MX beamline I04-1 and XChem, Diamond Light Source
web: https://www.diamond.ac.uk/Instruments/Mx/Fragment-Screening.html
ORCID: 0000-0003-0378-0017
| Google Scholar
Project 2 Lead: Target enablement; Structural Biology Core Lead; high-throughput structural biology; fragment screening

Karla Kirkegaard
Project Lead
Violetta L. Horton Professor, Department of Genetics, Stanford University School of Medicine
web: https://web.stanford.edu/group/kirkegaard/karla.html
ORCID: 0000-0001-7628-3770
| Google Scholar
Project 1 Lead: Antiviral Targeting to Suppress Drug Resistance

Nir London

Project Lead: Covalent Targeting Strategies; Core Lead: Biochemical Assay Core
Senior Scientist (Assistant Professor), Weizmann Institute of Science
web: https://www.weizmann.ac.il/Organic_Chemistry/London/home
ORCID: 0000-0003-2687-0699
| Google Scholar
Project Lead: Covalent Tareting Strategies
Core Leads

Frank von Delft

Project Lead: Target enablement ; Core Lead: Structural Biology Core
Principal Beamline Scientist, MX beamline I04-1 and XChem, Diamond Light Source
web: https://www.diamond.ac.uk/Instruments/Mx/Fragment-Screening.html
ORCID: 0000-0003-0378-0017
| Google Scholar
Project 2 Lead: Target enablement; Structural Biology Core Lead; high-throughput structural biology; fragment screening

Kris White
Core Lead: Antiviral Efficacy and Resistance Core
Assistant Professor, Icahn School of Medicine at Mount Sinai
web: https://labs.icahn.mssm.edu/garcia-sastre/kris-white-ph-d/
ORCID: 0000-0003-0889-0506
Core Lead: Antiviral Efficacy and Resistance Core; animal efficacy models; antiviral assays

Matthew Robinson

Core Lead: Data Infrastructure Core
Chief Technology Officer, PostEra
web: https://postera.ai/about/
Core Lead: Data Infrastructure Core

Nir London

Project Lead: Covalent Targeting Strategies; Core Lead: Biochemical Assay Core
Senior Scientist (Assistant Professor), Weizmann Institute of Science
web: https://www.weizmann.ac.il/Organic_Chemistry/London/home
ORCID: 0000-0003-2687-0699
| Google Scholar
Project Lead: Covalent Tareting Strategies
Co-Investigators

Adolfo García-Sastre
Co-Investigator: Antiviral Efficacy and Resistance Core
Professor of Microbiology, Icahn School of Medicine at Mount Sinai
Antiviral Efficacy and Resistance Core
web: https://icahn.mssm.edu/profiles/adolfo-garcia-sastre
ORCID: 0000-0002-6551-1827
virology; antiviral discovery; viral resistance

Celia Schiffer
Co-Investigator
Co-Investigator, UMass Chan Medical School
P1: Antiviral targeting
Co-Investigator

Dan Bolon

Co-Investigator
Co-Investigator, UMass Chan Medical School
P1: Antiviral targeting
ORCID: https://orcid.org/0000-0001-5857-6676
Co-Investigator

Daren Fearon

Co-Investigator: Structural Biology Core
Senior Beamline Scientist, Diamond Light Source
Structural Biology Core
web: https://www.diamond.ac.uk/Instruments/Mx/Fragment-Screening/XChem-Team/Fearon.html
ORCID: 0000-0003-3529-7863
high throughput X-ray structural biology; X-ray fragment screening; X-ray structure solution

Haim Barr
Co-Investigator: Biochemical Assay Core
Head of Drug Discovery and Medicinal Chemistry, INCPM, Weizmann Institute of Science
P1: Biochemical Assay Core
P1: Biochemical Assay Core
web: https://www.linkedin.com/in/haim-barr-4894907/?originalSubdomain=il
| Google Scholar
assay development; high-throughput biochemical assays

Jesse Bloom

Co-Investigator: Antiviral Targeting to Suppress Resistance
Associate Professor, Fred Hutchinson Cancer Research Center; Investigator, Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center; Howard Hughes Medical Institute
P1: Antiviral targeting
web: https://www.fredhutch.org/en/faculty-lab-directory/bloom-jesse.html
ORCID: 0000-0003-1267-3408
| Google Scholar
deep mutational scanning; viral bioinformatics; antiviral resistance

John D. Chodera

Principal Investigator; Co-Investigator: Hit-to-Lead; Co-Investigator: Lead Optimization
Associate Member, Sloan Kettering Institute
web: http://choderalab.org
ORCID: 0000-0003-0542-119X
| Google Scholar
Contact PI; Oversight of cores; Alchemical free energy calculations on Folding@home; computational chemistry and structure-based machine learning

Laurent Fraisse
Co-Investigator: Preclinical Development
Research and Development Director, Drugs for Neglected Diseases initiative (DNDi)
P6: Preclinical Development
web: https://dndi.org/our-people/laurent-fraisse/
preclinical development; neglected diseases; global equitable access

Martin Walsh

Co-Investigator: Target Enablement; Co-Investigator: Structural Biology Core
Deputy Director of Life Sciences, Diamond Light Source
web: https://www.diamond.ac.uk/Instruments/Mx/Research/Walsh-group/Staff/Martin-Walsh.html
ORCID: 0000-0001-5683-1151
protein expression; high throughput X-ray structural biology; X-ray fragment screening; X-ray structure solution

Matt Bogyo
Co-Investigator
Professor of Pathology, Professor of Microbiology and Immunology, Professor by courtesy of Chemical and Systems Biology, Stanford University School of Medicine
web: https://med.stanford.edu/bogyolab.html
ORCID: 0000-0003-3753-4412
protease targeting; covalent targeting strategies

Matt Evans

Co-Investigator
Co-Investigator, Mount Sinai
P1: Antiviral targeting
ORCID: 0000-0002-4991-3877
Co-Investigator

Pascale Boulet
Co-Investigator
ASAP IP Strategy Consultant, Intellectual Property & Access Leader, DNDi., Drugs for Neglected Diseases Initiative (DNDi)
P6: Preclinical development
ORCID: https://orcid.org/0000-0003-0542-119X
Regulatory

Peter Sjö
Principal Investigator; Co-Investigator: Preclinical Development
Head of Drug Discovery Programme, Drugs for Neglected Diseases initiative (DNDi)
web: https://dndi.org/our-people/peter-sjo/
ORCID: 0000-0002-6768-0536
| Google Scholar
Oversight of late-stage discovery and preclinical development; preclinical development; medicinal chemistry

Randy Albrecht
Co-Investigator: Antiviral Resistance and Efficacy Core
Associate Professor, Icahn School of Medicine at Mount Sinai
web: https://www.mountsinai.org/profiles/randy-a-albrecht
| Google Scholar
virology; animal efficacy models of viral respiratory disease
Scientists and Collaborators

Adolfo García-Sastre
Co-Investigator: Antiviral Efficacy and Resistance Core
Professor of Microbiology, Icahn School of Medicine at Mount Sinai
Antiviral Efficacy and Resistance Core
web: https://icahn.mssm.edu/profiles/adolfo-garcia-sastre
ORCID: 0000-0002-6551-1827
virology; antiviral discovery; viral resistance

Akbar Ali
, UMass Chan Medical School
P1: Antiviral targeting

Ala Shaqra
Scientist
Scientist, UMass Chan Medical School
P1: Antiviral targeting
Scientist

Alexander Matthew Payne

Researcher: Computational Chemistry Core
PhD Candidate, Memorial Sloan Kettering Center for Cancer Research
web: https://linktr.ee/alexandermatthewpayne
ORCID: 0000-0003-0947-0191
| Google Scholar
docking; free energy calculations; pan-family design

Alpha Lee

Principal Investigator; Project Lead: Hit-to-lead
Co-Founder and Chief Scientific Officer, PostEra
web: http://postera.ai
ORCID: 0000-0002-9616-3108
| Google Scholar
Oversight of early-stage discovery; artificial intelligence and machine learning for virtual synthetic libraries and automated ligand optimization; automated hit-to-lead optimization

Andre Schützer de Godoy
Scientist
Professor, Universidade de São Paulo (USP). Instituto de Física de São Carlos (IFSC)
web: https://bv.fapesp.br/en/pesquisador/80962/andre-schutzer-de-godoy/
ORCID: 0000-0002-0613-9164
| Google Scholar
structural biology; cryo-EM; X-ray structures; protein biochemistry; SARS-CoV-2 proteases

Annette von Delft
Project Lead: Preclinical Development
Translational Scientist, MedChemica Ltd
web: https://www.linkedin.com/in/annette-von-delft-56113093/?originalSubdomain=uk
| Google Scholar
translational science; preclinical development

Benjamin Kaminow

Unfunded collaborator
Unfunded collaborator, Sloan Kettering Institute for Cancer Research
Computational Chemistry Core
ORCID: https://orcid.org/0000-0002-2266-3353
Unfunded collaborator

Benjamin Perry
Former PI
Former PI, Drugs for Neglected Diseases Initiative
Former PI

Blake Balcomb
Post Doc
Post Doc, Diamond Light Source
Structural Biology Core
ORCID: https://orcid.org/0000-0001-7599-8467
Post Doc

Brian Marsden

Other Personnel
Other Personnel, University of Oxford
P2: Target enablement
ORCID: https://orcid.org/0000-0002-1937-4091
Other Personnel

Briana McGovern

Scientist
Scientist, Mount Sinai
Antiviral Efficacy and Resistance Core
ORCID: https://orcid.org/0000-0002-0492-9904
Scientist

Bruce Lefker
Consultant
Consultant, Thames Pharma Partners
P3: Fragment-to-lead and target validation, P5: Lead optimization
Consultant

Charlie Tomlinson
Scientist
Scientist, Diamond Light Source
Structural Biology Core
ORCID: https://orcid.org/0000-0002-1845-6028
Scientist

Charline Giroud
Scientist
Scientist, University of Oxford
P2: Target enablement
Scientist

Conor Wild

Post Doc
Post Doc, Diamond Light Source
P2: Target enablement, Structural Biology Core
P2: Target enablement, Structural Biology Core
ORCID: https://orcid.org/0000-0003-0654-8141
Post Doc

Daren Fearon

Co-Investigator: Structural Biology Core
Senior Beamline Scientist, Diamond Light Source
Structural Biology Core
web: https://www.diamond.ac.uk/Instruments/Mx/Fragment-Screening/XChem-Team/Fearon.html
ORCID: 0000-0003-3529-7863
high throughput X-ray structural biology; X-ray fragment screening; X-ray structure solution

David Cousins
Scientist
Scientist, MedChemica
P5: Lead optimization
ORCID: 0000-0001-9945-769X
Scientist

David Dotson

Scientist
Scientist, Sloan Kettering Institute for Cancer Research
Computational Chemistry Core
ORCID: https://orcid.org/0000-0001-5879-2942
Scientist

Ed Griffen

Project Lead: Lead Optimization
Technical Director, MedChemica Consultancy Ltd and MedChemical Ltd, MedChemica Ltd
web: https://www.target2035.net/biosketches/ed-griffen-medchemica-ltd
| Google Scholar
Project Lead: Lead Optimization; medicinal chemistry; lead optimization; hit-to-lead

Eleanor Williams
Scientific Coordinator
Scientific Coordinator, University of Oxford
P2: Target enablement
ORCID: 0000-0002-1331-9518
Scientific Coordinator

Frank von Delft

Project Lead: Target enablement ; Core Lead: Structural Biology Core
Principal Beamline Scientist, MX beamline I04-1 and XChem, Diamond Light Source
web: https://www.diamond.ac.uk/Instruments/Mx/Fragment-Screening.html
ORCID: 0000-0003-0378-0017
| Google Scholar
Project 2 Lead: Target enablement; Structural Biology Core Lead; high-throughput structural biology; fragment screening

Gwendolyn Fate
Consultant
Consultant, Thames Pharma Partners
P6: Preclinical development and translation
Consultant

Haim Barr
Co-Investigator: Biochemical Assay Core
Head of Drug Discovery and Medicinal Chemistry, INCPM, Weizmann Institute of Science
P1: Biochemical Assay Core
P1: Biochemical Assay Core
web: https://www.linkedin.com/in/haim-barr-4894907/?originalSubdomain=il
| Google Scholar
assay development; high-throughput biochemical assays

Hugo Macdermott-Opeskin

Consultant
Consultant, Sloan Kettering Institute for Cancer Research
Computational Chemistry Core
ORCID: https://orcid.org/0000-0002-7393-7457
Consultant

Isabelle Amick

Scientist
Scientist, PostEra Inc.
P3: Fragment-to-lead and target validation
ORCID: https://orcid.org/0000-0001-7876-4842
Scientist

Iván Pulido

Software Engineer
Software Engineer, Sloan Kettering Institute for Cancer Research
Computational Chemistry Core
ORCID: https://orcid.org/0000-0002-7178-8136
Software Engineer

Jared Benjamin
Scientist
Scientist, Mount Sinai
Antiviral Efficacy and Resistance Core
ORCID: https://orcid.org/0000-0002-0328-0461
Scientist

Jasmin Aschenbrenner
Post Doc
Post Doc, Diamond Light Source
Structural Biology Core
ORCID: https://orcid.org/0000-0002-4318-0481
Post Doc

Jenke Scheen

Researcher
Scientist, Open Molecular Software Foundation
web: https://www.linkedin.com/in/jenkescheen/
ORCID: 0000-0001-9781-0445
| Google Scholar
Alchemical free energy calculations on Folding@home; project support

Jerry Yap
Scientist
Medicinal Chemist, PostEra Inc.
Computational Chemistry Core, Data Core, P3: Fragment-to-lead and target validation
Computational Chemistry Core, Data Core, P3: Fragment-to-lead and target validation

Jesse Bloom

Co-Investigator: Antiviral Targeting to Suppress Resistance
Associate Professor, Fred Hutchinson Cancer Research Center; Investigator, Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center; Howard Hughes Medical Institute
P1: Antiviral targeting
web: https://www.fredhutch.org/en/faculty-lab-directory/bloom-jesse.html
ORCID: 0000-0003-1267-3408
| Google Scholar
deep mutational scanning; viral bioinformatics; antiviral resistance

Jessica Stacey

Scientist
Scientist, MedChemica
P5: Lead optimization
ORCID: 0000-0001-6932-8539
Scientist

John D. Chodera

Principal Investigator; Co-Investigator: Hit-to-Lead; Co-Investigator: Lead Optimization
Associate Member, Sloan Kettering Institute
web: http://choderalab.org
ORCID: 0000-0003-0542-119X
| Google Scholar
Contact PI; Oversight of cores; Alchemical free energy calculations on Folding@home; computational chemistry and structure-based machine learning

Kate Fieseler

, University of Oxford
P2: Target enablement
ORCID: 0000-0003-0211-8558

Kris White
Core Lead: Antiviral Efficacy and Resistance Core
Assistant Professor, Icahn School of Medicine at Mount Sinai
web: https://labs.icahn.mssm.edu/garcia-sastre/kris-white-ph-d/
ORCID: 0000-0003-0889-0506
Core Lead: Antiviral Efficacy and Resistance Core; animal efficacy models; antiviral assays

Lauren Reid

Scientist
Scientist, MedChemica
P5: Lead optimization
ORCID: https://orcid.org/0000-0001-8327-0927
Scientist

Laurent Fraisse
Co-Investigator: Preclinical Development
Research and Development Director, Drugs for Neglected Diseases initiative (DNDi)
P6: Preclinical Development
web: https://dndi.org/our-people/laurent-fraisse/
preclinical development; neglected diseases; global equitable access

Lizbe Koekemoer

Scientific Coordinator
Scientific Coordinator, University of Oxford
P2: Target enablement
ORCID: https://orcid.org/0000-0001-9226-9127
Scientific Coordinator

Lucas Ferreira

Other Personnel
Other Personnel, University of Oxford
P2: Target enablement
ORCID: https://orcid.org/0000-0001-6397-357X
Other Personnel

Mario Rodríguez Monteverde
Scientist
Scientist, Mount Sinai
Antiviral Efficacy and Resistance Core
Scientist

Martin Walsh

Co-Investigator: Target Enablement; Co-Investigator: Structural Biology Core
Deputy Director of Life Sciences, Diamond Light Source
web: https://www.diamond.ac.uk/Instruments/Mx/Research/Walsh-group/Staff/Martin-Walsh.html
ORCID: 0000-0001-5683-1151
protein expression; high throughput X-ray structural biology; X-ray fragment screening; X-ray structure solution

Matteo Ferla
Post Doc
Post Doc, University of Oxford
P2: Target enablement
ORCID: https://orcid.org/0000-0002-5508-4673
Post Doc

Matthew Robinson

Core Lead: Data Infrastructure Core
Chief Technology Officer, PostEra
web: https://postera.ai/about/
Core Lead: Data Infrastructure Core

Melissa Boby

Unfunded collaborator
Unfunded collaborator, Sloan Kettering Institute for Cancer Research
Computational Chemistry Core
ORCID: https://orcid.org/0000-0003-1920-206X
Unfunded collaborator

Michael Fairhead

Post Doc
Post Doc, University of Oxford
P2: Target enablement
ORCID: 0000-0001-5361-3933
Post Doc

Michael Retchin
Student
Student, Sloan Kettering Institute for Cancer Research
Computational Chemistry Core
ORCID: https://orcid.org/0000-0001-9822-8318
Student

Michael Williams
Scientist
Scientist, Mount Sinai
Antiviral Efficacy and Resistance Core
Scientist

Mike Henry

Scientist
Scientist, Sloan Kettering Institute for Cancer Research
Computational Chemistry Core
ORCID: 0000-0002-3870-9993
Scientist

Nese Kurt Yilmaz
, UMass Chan Medical School
P1: Antiviral targeting

Nir London

Project Lead: Covalent Targeting Strategies; Core Lead: Biochemical Assay Core
Senior Scientist (Assistant Professor), Weizmann Institute of Science
web: https://www.weizmann.ac.il/Organic_Chemistry/London/home
ORCID: 0000-0003-2687-0699
| Google Scholar
Project Lead: Covalent Tareting Strategies

Noa Lahav

Scientist
Scientist, Weizmann Institute of Science
Biochemical Assay Core
ORCID: N/A
Scientist

Oleg Fedorov
Other Personnel
Other Personnel, University of Oxford
P2: Target enablement
Other Personnel

Peter Marples
Research Assistant
Research Assistant, Diamond Light Source
P2: Target enablement, Structural Biology Core
P2: Target enablement, Structural Biology Core
ORCID: 0000-0002-8787-7969
Research Assistant

Peter Sjö
Principal Investigator; Co-Investigator: Preclinical Development
Head of Drug Discovery Programme, Drugs for Neglected Diseases initiative (DNDi)
web: https://dndi.org/our-people/peter-sjo/
ORCID: 0000-0002-6768-0536
| Google Scholar
Oversight of late-stage discovery and preclinical development; preclinical development; medicinal chemistry

Ralph Robinson
Consultant
Consultant, Thames Pharma Partners
P3: Fragment-to-lead and target validation, P5: Lead optimization
Consultant

Randy Albrecht
Co-Investigator: Antiviral Resistance and Efficacy Core
Associate Professor, Icahn School of Medicine at Mount Sinai
web: https://www.mountsinai.org/profiles/randy-a-albrecht
| Google Scholar
virology; animal efficacy models of viral respiratory disease

Randy Diaz-Tapia
Scientist
Scientist, Mount Sinai
Antiviral Efficacy and Resistance Core
Scientist

Rebecca Hertzman
Student
Student, Weizmann Institute of Science
P4: Covalent targeting strategies
Student

Romel Rosales
Post Doc
Post Doc, Mount Sinai
Antiviral Efficacy and Resistance Core
Post Doc

Ruben Garcia Sanchez

Post Doc
Post Doc, University of Oxford
P2: Target enablement
ORCID: https://orcid.org/0000-0001-6156-3542
Post Doc

Ryan Lithgo
Post Doc
Post Doc, Diamond Light Source
Structural Biology Core
ORCID: https://orcid.org/0000-0002-4706-9916
Post Doc

Sarah Duggan
, UMass Chan Medical School
P1: Antiviral targeting
ORCID: https://orcid.org/0000-0003-0282-1809

Tamas Szommer
Scientific Coordinator
, University of Oxford
P2: Target enablement
ORCID: 0000-0002-3811-4068

Tyler Starr

Postdoctoral Research Fellow: Antiviral Targeting to Suppress Resistance
Associate Professor, Fred Hutchinson Cancer Research Center, Fred Hutchinson Cancer Research Center
web: https://www.linkedin.com/in/tyler-starr-06a1b3172/
ORCID: 0000-0001-6713-6904
| Google Scholar
deep mutational scanning; viral bioinformatics; antiviral resistance

Warren Thompson

Post Doc
Post Doc, Diamond Light Source
P2: Target enablement, Structural Biology Core
P2: Target enablement, Structural Biology Core
ORCID: 0000-0003-1474-7810
Post Doc

Xiaomin Ni
Scientist
Scientist, University of Oxford
P2: Target enablement
ORCID: https://orcid.org/0000-0002-7769-8297
Scientist
Administrative Core
Ashley Souffront
Project manager
Project manager, Sloan Kettering Institute for Cancer Research
Administrative Core
Project manager

Erica Goldberger

Unfunded collaborator
Unfunded collaborator, Sloan Kettering Institute for Cancer Research
Administrative Core
ORCID: 0000-0002-0642-7107
Unfunded collaborator

Jessie Slater
Project Manager
Project Manager, Sloan Kettering Institute for Cancer Research
Administrative Core
Other Personnel
Maggie Jameson
Administrative Director
Administrative Director, Sloan Kettering Institute for Cancer Research
Administrative Core
Administrative Director